Syphilis Research Today is a free monthly online journal that collates and summarizes the latest research about Syphilis, including details on causes, symptoms, treatment, prevention.

Secondary syphilis with ocular manifestations in older adults.

Maves RC, Cachay ER, Young MA, Fierer J

United States Naval Medical Research Center Detachment, Lima, Peru. Ryan.Maves@med.navy.mil

We describe 4 patients (age, >50 years) with secondary syphilis. All patients presented with ocular syphilis, and 2 presented with syphilis-negative rapid plasma reagin titers due to a prozone phenomenon. Three male patients reported sildenafil use. The presentation of these patients with ocular syphilis suggests the need for additional clinical studies involving older patients.

Published 10 June 2008 in Clin Infect Dis, 46(12): e142-5.
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Articles on Syphilis published 13 May 2008:

Awareness of the Tuskegee Syphilis Study and the US presidential apology and their influence on minority participation in biomedical research.   Am J Public Health, 98(6): 1137-42.

OBJECTIVES: We compared the influence of awareness of the Tuskegee Syphilis Study and the presidential apology for that study on the willingness of Blacks, non-Hispanic Whites, and Hispanics to participate in biomedical research. METHODS: The Tuskegee Legacy Project Questionnaire was administered to 1133 adults in 4 US cities. This 60-item questionnaire addressed issues related to the recruitment of minorities into biomedical studies. RESULTS: Adjusted multivariate analysis showed that, ... [Abstract] [Full-text]

Articles on Syphilis published 28 April 2008:

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AIM: To examine the clinical manifestations of syphilitic uveitis in a population and review trends in incidence at a tertiary referral centre. METHODS: A retrospective, non-comparative interventional case series of 22 consecutive patients with syphilitic uveitis who were managed in the Ocular Inflammation and Immunology Services of the Singapore National Eye Centre between 1995 and 2006. RESULTS: Twenty-two patients (mean age 52.7 years, range 18-78) with a positive serum fluorescent ... [Abstract] [Full-text]

Articles on Syphilis published 14 April 2008:

Narrative constructions of health care issues and policies: the case of President Clinton's apology-by-proxy for the Tuskegee syphilis experiment.   J Med Humanit, 29(2): 89-109.

The Tuskegee Syphilis Experiment (TSE) has shaped African Americans' views of the American health care system, contributing to a reluctance to participate in biomedical research and a suspicion of the medical system. This essay examines public discourses surrounding President Clinton's attempt to restore African Americans' trust by apologizing for the TSE. Through a narrative reading, we illustrate the failure of this text as an attempt to reconcile the United States Public Health Service and ... [Abstract] [Full-text]

Articles on Syphilis published 14 March 2008:

Otosyphilis in HIV-coinfected individuals: a case series from Toronto, Canada.   AIDS Patient Care STDS, 22(3): 213-9.

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Articles on Syphilis published 28 February 2008:

PCR testing for Treponema pallidum in paraffin-embedded skin biopsy specimens: test design and impact on the diagnosis of syphilis.   J Clin Pathol, 61(3): 390-5.

BACKGROUND: Syphilis, a chronic infection caused by Treponema pallidum, is a disease which is increasing in incidence, and thus more and more becoming a differential diagnosis in routine pathology. AIMS: To develop a PCR-based molecular assay for the detection of T pallidum in formalin-fixed, paraffin-embedded tissues, and evaluate its diagnostic power, especially in comparison with other ancillary methods (immunohistochemistry and Dieterle staining). METHODS: 36 skin biopsy specimens with the ... [Abstract] [Full-text]

Articles on Syphilis published 14 February 2008:

Inguinal phlegmon and positive serology for syphilis after penile bite laceration: true, true and unrelated.   Am J Emerg Med, 26(2): 250.e7-8.

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Short-term impact evaluation of a social marketing campaign to prevent syphilis among men who have sex with men.   Am J Public Health, 98(2): 337-43.

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Articles on Syphilis published 21 December 2007:

Maternal Herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study.   AIDS, 22(2): 193-201.

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